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1

Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease

Niswender, Colleen M., Conn, P. Jeffrey

Journal:

Annual Review of Pharmacology

Year:

2010

Language:

english

File:

PDF, 609 KB

english, 2010

2

Pharmacological Treatments for Autism Spectrum Disorder: Will Emerging Approaches Yield New Treatments?

Gogliotti, Rocco G, Conn, P Jeffrey

Journal:

Neuropsychopharmacology

Year:

2016

Language:

english

File:

PDF, 123 KB

english, 2016

3

mGlu2 and mGlu3 Negative Allosteric Modulators Divergently Enhance Thalamocortical Transmission and Exert Rapid Antidepressant-like Effects

Joffe, Max E., Santiago, Chiaki I., Oliver, Kendra H., Maksymetz, James, Harris, Nicholas A., Engers, Julie L., Lindsley, Craig W., Winder, Danny G., Conn, P. Jeffrey

Journal:

Year:

2019

Language:

english

File:

PDF, 3.85 MB

english, 2019

4

Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moieties

Thomas M. Bridges, Ashley E. Brady, J. Phillip Kennedy, R. Nathan Daniels, Nicole R. Miller, Kwango Kim, Micah L. Breininger, Patrick R. Gentry, John T. Brogan, Carrie K. Jones, P. Jeffrey Conn, Craig

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 207 KB

english, 2008

5

Metabotropic Excitatory Amino Acid Receptor Activation Stimulates Phospholipase D in Hippocampal Slices

Valerie Boss, P. Jeffrey Conn

Journal:

Journal of Neurochemistry

Year:

1992

Language:

english

File:

PDF, 409 KB

english, 1992

6

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

Jeffrey Conn, P., Christopoulos, Arthur, Lindsley, Craig W.

Journal:

Nature Reviews Drug Discovery

Year:

2009

Language:

english

File:

PDF, 553 KB

english, 2009

7

PHARMACOLOGY AND FUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTORS

Conn, P. Jeffrey, Pin, Jean-Philippe

Journal:

Annual Review of Pharmacology

Year:

1997

Language:

english

File:

PDF, 300 KB

english, 1997

8

Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 1: Development of a potent and CNS penetrant [3.1.0]-based lead

Jones, Carrie K., Sheffler, Douglas J., Williams, Richard, Jadhav, Sataya B., Felts, Andrew S., Morrison, Ryan D., Niswender, Colleen M., Daniels, J. Scott, Conn, P. Jeffrey, Lindsley, Craig W.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.70 MB

english, 2014

9

Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders

Conn, P. Jeffrey, Lindsley, Craig W., Meiler, Jens, Niswender, Colleen M.

Journal:

Nature Reviews Drug Discovery

Year:

2014

Language:

english

File:

PDF, 1.41 MB

english, 2014

10

Development of Novel, CNS Penetrant Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 1 (mGlu 1 ), Based on an N -(3-Chloro-4-(1,3-dioxoisoindolin-2-yl)phenyl)-3-methylfuran-2-carboxamide Scaffold, That Potentiate Wild Type and Mutant mGlu 1 Receptors Found in Schizophrenics

Garcia-Barrantes, Pedro M., Cho, Hyekyung P., Niswender, Colleen M., Byers, Frank W., Locuson, Charles W., Blobaum, Anna L., Xiang, Zixiu, Rook, Jerri M., Conn, P. Jeffrey, Lindsley, Craig W.

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 4.07 MB

english, 2015

11

The Metabotropic Glutamate Receptor 4 Positive Allosteric Modulator ADX88178 Inhibits Inflammatory Responses in Primary Microglia

Ponnazhagan, Ranjani, Harms, Ashley S., Thome, Aaron D., Jurkuvenaite, Asta, Gogliotti, Rocco, Niswender, Colleen M., Conn, P. Jeffrey, Standaert, David G.

Journal:

Journal of Neuroimmune Pharmacology

Year:

2016

Language:

english

File:

PDF, 714 KB

english, 2016

12

Novel PAMs Targeting NMDAR GluN2A Subunit

Xiang, Zixiu, Conn, P. Jeffrey

Journal:

Year:

2016

Language:

english

File:

PDF, 244 KB

english, 2016

13

Grey Literature in Meta-Analyses

Conn, Vicki S., Valentine, Jeffrey C., Cooper, Harris M., Rantz, Marilyn J.

Journal:

Nursing Research

Year:

2003

Language:

english

File:

PDF, 92 KB

english, 2003

14

Pick Your Model Wisely: Understanding the Negative Symptoms of Schizophrenia in Rodent Models

Yohn, Samantha E., Conn, P. Jeffrey

Journal:

ACS Chemical Neuroscience

Year:

2018

Language:

english

File:

PDF, 434 KB

english, 2018

15

Kinetic and system bias as drivers of metabotropic glutamate receptor 5 allosteric modulator pharmacology

Sengmany, Kathy, Hellyer, Shane D., Albold, Sabine, Wang, Taide, Conn, P. Jeffrey, May, Lauren T., Christopoulos, Arthur, Leach, Katie, Gregory, Karen J.

Journal:

Neuropharmacology

Year:

2019

Language:

english

File:

PDF, 2.23 MB

english, 2019

16

Neuropharmacological Insight from Allosteric Modulation of mGlu Receptors

Stansley, Branden J., Conn, P. Jeffrey

Journal:

Trends in Pharmacological Sciences

Year:

2019

Language:

english

File:

PDF, 1.97 MB

english, 2019

17

Shared Behavioral and Neurocircuitry Disruptions in Drug Addiction, Obesity and Binge Eating Disorder: Focus on Group I mGluRs in the Mesolimbic Dopamine Pathway

Yohn, Samantha, Galbraith, Jordan, Calipari, Erin, Conn, P. Jeffrey

Journal:

ACS Chemical Neuroscience

Year:

2019

Language:

english

File:

PDF, 1.50 MB

english, 2019

18

Chemical Exchange of Hydroxyl Groups in Lipidic Cubic Phases Characterized by NMR

Meikle, Thomas G., Keizer, David W., Babon, Jeffrey J., Drummond, Calum J., Separovic, Frances, Conn, Charlotte E., Yao, Shenggen

Journal:

Journal of Physical Chemistry B

Year:

2020

File:

PDF, 3.38 MB

2020

19

Heterogeneity of metabotropic glutamate receptors in autonomic cell groups of the medulla oblongata of the rat

Hay, Meredith, McKenzie, Heather, Lindsley, Kathy, Dietz, Nancy, Bradley, Stefania R., Conn, P. Jeffrey, Hasser, Eileen M.

Journal:

The Journal of Comparative Neurology

Year:

1999

Language:

english

File:

PDF, 1.11 MB

english, 1999

20

Immunohistochemical localization of subtype 4a metabotropic glutamate receptors in the rat and mouse basal ganglia

Bradley, Stefania Risso, Standaert, David G., Rhodes, Kenneth J., Rees, Howard D., Testa, Claudia M., Levey, Allan I., Conn, P. Jeffrey

Journal:

The Journal of Comparative Neurology

Year:

1999

Language:

english

File:

PDF, 1.26 MB

english, 1999

21

Localization of metabotropic glutamate receptor 7 mRNA and mGluR7a protein in the rat basal ganglia

Kosinski, Christoph M., Risso Bradley, Stefania, Conn, P. Jeffrey, Levey, Allan I., Landwehrmeyer, G. Bernhard, Penney, John B., Young, Anne B., Standaert, David G.

Journal:

The Journal of Comparative Neurology

Year:

1999

Language:

english

File:

PDF, 2.13 MB

english, 1999

22

Roles of metabotropic glutamate receptors in glial function and glial-neuronal communication

Danny G. Winder, P. Jeffrey Conn

Journal:

Journal of Neuroscience Research

Year:

1996

Language:

english

File:

PDF, 826 KB

english, 1996

23

Functional downregulation of GluR2 in piriform cortex of kindled animals

Heather C. Prince, Anastassios V. Tzingounis, Allan I. Levey, P. Jeffrey Conn

Journal:

Year:

2000

Language:

english

File:

PDF, 141 KB

english, 2000

24

Up-regulation of the metabotropic glutamate receptor mGluR4 in hippocampal neurons with reduced seizure vulnerability

Ailing A. Lie, Albert Becker, Karsten Behle, Heinz Beck, Barbara Malitschek, P. Jeffrey Conn, Rainer Kuhn, Robert Nitsch, Martina Plaschke, Johannes Schramm, Christian E. Elger, Otmar D. Wiestler, Ing

Journal:

Annals of Neurology

Year:

2000

Language:

english

File:

PDF, 4.74 MB

english, 2000

25

ChemInform Abstract: Synthesis and SAR of a Novel Positive Allosteric Modulator (PAM) of the Metabotropic Glutamate Receptor 4 (mGluR4).

Richard Williams, Kari A. Johnson, Patrick R. Gentry, Colleen M. Niswender, Charles D. Weaver, P. Jeffrey Conn, Craig W. Lindsley, Corey R. Hopkins

Journal:

Year:

2010

File:

PDF, 16 KB

2010

26

ChemInform Abstract: Chemical Lead Optimization of a Pan Gq mAChR M1, M3, M5 Positive Allosteric Modulator (PAM) Lead. Part 1. Development of the First Highly Selective M5 PAM (I).

Thomas M. Bridges, J. Phillip Kennedy, Hyekyung P. Cho, Micah L. Breininger, Patrick R. Gentry, Corey R. Hopkins, P. Jeffrey Conn, Craig W. Lindsley

Journal:

Year:

2010

File:

PDF, 19 KB

2010

27

ChemInform Abstract: Synthesis and SAR of Novel, 4-(Phenylsulfamoyl)phenylacetamide mGlu4 Positive Allosteric Modulators (PAMs) Identified by Functional High-Throughput Screening (HTS).

Darren W. Engers, Patrick R. Gentry, Richard Williams, Julie D. Bolinger, C. David Weaver, Usha N. Menon, P. Jeffrey Conn, Craig W. Lindsley, Colleen M. Niswender, Corey R. Hopkins

Journal:

Year:

2011

File:

PDF, 23 KB

2011

28

Synthesis, SAR and Unanticipated Pharmacological Profiles of Analogues of the mGluR5 Ago-potentiator ADX-47273

Darren W. Engers, Alice L. Rodriguez, Richard Williams, Alexis S. Hammond, Daryl Venable, Oluwatomi Oluwatola, Gary A. Sulikowski, P. Jeffrey Conn, Craig W. Lindsley

Journal:

Year:

2009

Language:

english

File:

PDF, 305 KB

english, 2009

29

Synthesis and Structure–Activity Relationships of Allosteric Potentiators of the M4 Muscarinic Acetylcholine Receptor

J. Phillip Kennedy, Thomas M. Bridges, Patrick R. Gentry, John T. Brogan, Alexander S. Kane, Carrie K. Jones, Ashley E. Brady, Jana K. Shirey, P. Jeffrey Conn, Craig W. Lindsley

Journal:

Year:

2009

Language:

english

File:

PDF, 365 KB

english, 2009

30

Pharmacology and physiology of metabotropic glutamate receptors in mammalian central nervous system

P. Jeffrey Conn, Manisha A. Desai

Journal:

Drug Development Research

Year:

1991

Language:

english

File:

PDF, 1.70 MB

english, 1991

31

Distinct physiological roles of the Gq-coupled metabotropic glutamate receptors co-expressed in the same neuronal populations

Ornella Valenti, P. Jeffrey Conn, Michael J. Marino

Journal:

Journal of Cellular Physiology

Year:

2002

Language:

english

File:

PDF, 161 KB

english, 2002

32

Synthesis and SAR of analogs of the M1 allosteric agonist TBPB. Part II: Amides, sulfonamides and ureas—The effect of capping the distal basic piperidine nitrogen

Nicole R. Miller, R. Nathan Daniels, Thomas M. Bridges, Ashley E. Brady, P. Jeffrey Conn, Craig W. Lindsley

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 413 KB

english, 2008

33

A novel class of H3 antagonists derived from the natural product guided synthesis of unnatural analogs of the marine bromopyrrole alkaloid dispyrin

J. Phillip Kennedy, P. Jeffrey Conn, Craig W. Lindsley

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 2.22 MB

english, 2009

34

Synthesis and SAR of a mGluR5 allosteric partial antagonist lead: Unexpected modulation of pharmacology with slight structural modifications to a 5-(phenylethynyl)pyrimidine scaffold

Sameer Sharma, Alice L. Rodriguez, P. Jeffrey Conn, Craig W. Lindsley

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 270 KB

english, 2008

35

Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4): Part I. Discovery of pyrazolo[3,4-d]pyrimidines as novel mGluR4 positive allosteric modulators

Colleen M. Niswender, Evan P. Lebois, Qingwei Luo, Kwangho Kim, Hubert Muchalski, Huiyong Yin, P. Jeffrey Conn, Craig W. Lindsley

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 406 KB

english, 2008

36

Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4). Part II: Challenges in hit-to-lead

Richard Williams, Colleen M. Niswender, Qingwei Luo, Uyen Le, P. Jeffrey Conn, Craig W. Lindsley

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 231 KB

english, 2009

37

Discovery and SAR of novel mGluR5 non-competitive antagonists not based on an MPEP chemotype

Alice L. Rodriguez, Richard Williams, Ya Zhou, Stacey R. Lindsley, Uyen Le, Mark D. Grier, C. David Weaver, P. Jeffrey Conn, Craig W. Lindsley

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 1.43 MB

english, 2009

38

Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5

Andrew S. Felts, Sam A. Saleh, Uyen Le, Alice L. Rodriguez, C. David Weaver, P. Jeffrey Conn, Craig W. Lindsley, Kyle A. Emmitte

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 227 KB

english, 2009

39

Synthesis and SAR of novel, non-MPEP chemotype mGluR5 NAMs identified by functional HTS

Ya Zhou, Alice L. Rodriguez, Richard Williams, C. David Weaver, P. Jeffrey Conn, Craig W. Lindsley

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 472 KB

english, 2009

40

Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M5 PAM

Thomas M. Bridges, J. Phillip Kennedy, Hyekyung P. Cho, Micah L. Breininger, Patrick R. Gentry, Corey R. Hopkins, P. Jeffrey Conn, Craig W. Lindsley

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 579 KB

english, 2010

41

Synthesis and SAR of N-(4-(4-alklylpiperazin-1-yl)phenyl)benzamides as muscarinic acetylcholine receptor subtype 1 (M1) anatgonists

Nicole R. Miller, R. Nathan Daniels, David Lee, P. Jeffrey Conn, Craig W. Lindsley

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 935 KB

english, 2010

42

3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu5: Identification of easily prepared tool compounds with CNS exposure in rats

Andrew S. Felts, Stacey R. Lindsley, Jeffrey P. Lamb, Alice L. Rodriguez, Usha N. Menon, Satyawan Jadhav, Carrie K. Jones, P. Jeffrey Conn, Craig W. Lindsley, Kyle A. Emmitte

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 224 KB

english, 2010

43

Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS)

Darren W. Engers, Patrick R. Gentry, Richard Williams, Julie D. Bolinger, C. David Weaver, Usha N. Menon, P. Jeffrey Conn, Craig W. Lindsley, Colleen M. Niswender, Corey R. Hopkins

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 1.16 MB

english, 2010

44

3D-QSAR CoMFA study of benzoxazepine derivatives as mGluR5 positive allosteric modulators

Edward W. Lowe Jr., Alysia Ferrebee, Alice L. Rodriguez, P. Jeffrey Conn, Jens Meiler

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 373 KB

english, 2010

45

Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators

Thomas M. Bridges, J. Phillip Kennedy, Corey R. Hopkins, P. Jeffrey Conn, Craig W. Lindsley

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 777 KB

english, 2010

46

Discovery of molecular switches within the ADX-47273 mGlu5 PAM scaffold that modulate modes of pharmacology to afford potent mGlu5 NAMs, PAMs and partial antagonists

Jeffrey P. Lamb, Darren W. Engers, Colleen M. Niswender, Alice L. Rodriguez, Daryl F. Venable, P. Jeffrey Conn, Craig W. Lindsley

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 1.04 MB

english, 2011

47

Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): The development of ML169, an MLPCN probe

Paul R. Reid, Thomas M. Bridges, Douglas J. Sheffler, Hyekyung P. Cho, L. Michelle Lewis, Emily Days, J. Scott Daniels, Carrie K. Jones, Colleen M. Niswender, C. David Weaver, P. Jeffrey Conn, Craig W

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 1.05 MB

english, 2011

48

Design and synthesis of substituted N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides as positive allosteric modulators of the metabotropic glutamate receptor subtype 5

Mu-Fa Zou, Jianjing Cao, Alice L. Rodriguez, P. Jeffrey Conn, Amy Hauck Newman

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 510 KB

english, 2011

49

Synthesis and SAR of centrally active mGlu5 positive allosteric modulators based on an aryl acetylenic bicyclic lactam scaffold

Richard Williams, Jason T. Manka, Alice L. Rodriguez, Paige N. Vinson, Colleen M. Niswender, C. David Weaver, Carrie K. Jones, P. Jeffrey Conn, Craig W. Lindsley, Shaun R. Stauffer

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 1.00 MB

english, 2011

50

Potent mGluR5 antagonists: Pyridyl and thiazolyl-ethynyl-3,5-disubstituted-phenyl series

David Alagille, Herve DaCosta, Yelin Chen, Kamondanai Hemstapat, Alice Rodriguez, Ronald M. Baldwin, Jeffrey P. Conn, Gilles D. Tamagnan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 332 KB

english, 2011